Smith's bush squirrel is widely distributed across the savannas and woodlands of southern Africa, living in tree cavities and nests in environments where mopane and acacia grow. It is social, living in groups of 1–12 individuals that maintain bonds through grooming and vocalizations. Its diet is broad, including seeds, fruit, insects, tree sap, and even bird eggs. Breeding varies regionally but typically occurs once a year, with a gestation of about 50–60 days and litters of 1–4 young. Its conservation status is Least Concern.